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Brighter Future Initiative

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The Contribution of Choline to Cholesterol and its Connection to Cancers

What is Cholesterol?

Cholesterol is nothing new to most of us. It is a chemical compound required by the body as a building block for some hormones, vitamins, and for cell membranes. The liver is responsible for producing most of the cholesterol in the body while the rest is provided by dietary sources such as dairy products, fish, eggs, poultry, and meat. Plant-derived foods do not have any cholesterol.

The liver controls the cholesterol in the blood. Following a meal, dietary cholesterol is absorbed via the small intestine, metabolized and stored in the liver. The liver secretes cholesterol as is required by the body but when there is too much in the body, it can result in plaque buildup in arterial walls.

 

Good and bad cholesterol

There is good cholesterol and bad cholesterol all transported in the bloodstream by lipoproteins. LDL or Low-Density Lipoproteins are the types that adhere to arterial walls causing the buildup of plaque and narrowing of the arteries due to high cholesterol content.

HDL or High-Density Lipoproteins comprise of higher protein levels and lower cholesterol levels deeming them good cholesterol.

VLDL or Very Low-Density Lipoproteins have an even lower protein level compared to LDL and they have also been linked to plaque deposits. Choline in eggs is needed for phosphatidylcholine synthesis, an essential constituent of VLDLs which move cholesterol and fats from the liver. Lipids are ideally removed from the blood for cells to use as an energy source and the fat-soluble vitamins accompanying them are used for various crucial processes. When there is insufficient choline, there is an inefficient clearance of lipids which results in oxidation of the sensitive polyunsaturated fatty acids among them. They, in turn, become toxic to the blood vessels and the immune system clean everything up by forming plaques in the arteries. At first, this is protective but it can eventually lead to a stroke or a heart attack.

Poor clearance of lipids usually enhances LDL levels and these particles will begin oxidizing. However, the amount of oxidized LDL is usually cleared very rapidly from the bloodstream meaning that a higher oxidation rate may actually reduce LDL. Additionally, there are genetic differences among the different receptors which clear the oxidized LDL from the blood plasma resulting in additional contrasting influences on blood lipids.

 

 

<iframe width="560" height="315" src="https://www.youtube.com/embed/023jyVJ11J4" frameborder="0" allowfullscreen></iframe>

Too much choline—a compound concentrated in eggs and other animal products—can make bodily secretions smell like rotting fish, and may increase the risk of heart disease, due to conversion in the gut to trimethylamine.

The connection between choline in eggs and cancer

Eggs are one of the richest sources of choline and it has the potential to increase the occurrence of cancer, as well as its lethality and spread. One particular study indicated that individuals with the highest choline intake increased their risk of getting fatal prostate cancer by 70%. Another research project discovered there was an 81% increased risk of prostate cancer in men who ate more than 2 ½ eggs each week. This could be a result of the cholesterol found in eggs but it could also be due to choline in eggs. Eggs, milk, and meat have all been linked to advanced prostate cancer because of choline. Dietary choline is usually converted into trimethylamine in the gut so scientists have speculated that this TMAO due to increased dietary choline intake can increase inflammation which could encourage the progression of prostate cancer to a lethal degree.

Sources

https://www.westonaprice.org/why-is-my-cholesterol-so-high-on-this-diet/

https://www.westonaprice.org/does-dietary-choline-contribute-to-heart-disease/

https://chriskresser.com/choline-and-tmao-eggs-still-dont-cause-heart-disease/

https://www.benecol.co.uk/cholesterol

https://www.medicalnewstoday.com/articles/9152.php

https://heartuk.org.uk/health-and-high-cholesterol

https://nutritionfacts.org/video/eggs-choline-and-cancer/

 

Vegan for life ♥

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